Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24465404 | 0.89 | DNM1 (0.58) | DNM1SLC22A1MEN1THRBHTT | |
| SCHEMBL7115309 | 0.86 | DNM1 (0.50) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Fluoride Ion SCHEMBL10492866 | 0.83 | DNM1 (0.58) | DNM1SLC22A1MEN1THRBHTT | |
| SCHEMBL31302310 | 0.82 | SLC22A1 (0.62) | DNM1SLC22A1MEN1THRBHTT | |
| Hydrochloric Acid SCHEMBL19873261 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL19873263 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL1024140 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL19873253 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4001962 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL22204611 | 0.81 | DNM1 (0.94) | DNM1SLC22A1HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9511008-B2 | Conditioning composition for keratin fibres and its use | KAO GERMANY GMBH (DE) | 2016-12-06 | — | — | US | claimed |
| US-9511008-B2 | Conditioning composition for keratin fibres and its use | KAO GERMANY GMBH (DE) | 2016-12-06 | — | — | US | disclosed |
| EP-2424489-B1 | CONDITIONING COMPOSITION FOR HAIR | KAO GERMANY GMBH (DE) | 2016-10-05 | — | — | EP | disclosed |
| EP-2563322-B1 | PROCESS FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO WASHING | KAO GERMANY GMBH (DE) | 2016-10-05 | — | — | EP | disclosed |
| US-8523953-B2 | Use of an amine and/or a quaternary ammonium compound for protecting colour of artificially coloured hair with respect to the washing and process therefore | KAO GERMANY GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| US-20130112217-A1 | CONDITIONING COMPOSITION FOR HAIR | KAO GERMANY GMBH (DE) | 2013-05-09 | — | — | US | disclosed |
| EP-2563322-A2 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | Kao Germany GmbH (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2560607-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | Kao Germany GmbH (DE) | 2013-02-27 | — | — | EP | disclosed |
| US-20130037045-A1 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | KAO GERMANY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130032165-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KAO GERMANY GMBH (DE) | 2013-02-07 | — | — | US | disclosed |
| EP-2512421-A2 | CONDITIONING COMPOSITION FOR HAIR | Kao Germany GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2424489-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-Kao Professional Salon Services GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20120034182-A1 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2012-02-09 | — | — | US | disclosed |
| WO-2011134848-A2 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-11-03 | — | — | WO | disclosed |
| EP-2382962-A1 | Use of an amine and/or a quaternary ammonium compound for protecting colour of artificially coloured hair with respect to the washing and process therefore | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-11-02 | — | — | EP | disclosed |
| WO-2011131687-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-10-27 | — | — | WO | disclosed |
| EP-2380555-A1 | Conditioning composition for keratin fibres and its use | KPSS-Kao Professional Salon Services GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2011072853-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010124817-A2 | CONDITIONING COMPOSITION FOR HAIR | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130112217-A1 | CONDITIONING COMPOSITION FOR HAIR | AR, H1-4, H1-10 | DNM1 4579/4885SLC22A1 1602/4885MEN1 1983/4885 |
| US-20130037045-A1 | USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE | DOHH, HRH3, DAO | DNM1 2821/4885SLC22A1 3367/4885MEN1 3251/4885 |
| US-20120034182-A1 | CONDITIONING COMPOSITION FOR HAIR | MSRB3, H1-4, OR10J3 | DNM1 3666/4885SLC22A1 1005/4885MEN1 1885/4885 |
| US-20130032165-A1 | CONDITIONING COMPOSITION FOR KERATIN FIBRES AND ITS USE | KRT18, CD69, KAT5 | DNM1 4528/4885SLC22A1 3218/4885MEN1 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.