Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11680166 | 0.74 | BCHE (0.48) | MEN1KMT2AGAA | |
| SCHEMBL11680841 | 0.68 | HTR2A (0.57) | HDAC1HDAC8HDAC3HDAC2MEN1 | |
| SCHEMBL12558479 | 0.67 | PADI4 (0.55) | POLBMEN1KMT2APADI4TP53 | |
| SCHEMBL11681773 | 0.67 | MEN1 (0.46) | POLBMEN1KMT2ALMNATP53 | |
| SCHEMBL798123 | 0.66 | KMT2A (0.55) | POLBHDAC1HDAC8HDAC3HDAC2 | |
| Ammonia Solution, Strong SCHEMBL15466974 | 0.66 | PADI4 (0.53) | POLBMEN1KMT2APADI4TP53 | |
| SCHEMBL9210193 | 0.66 | PLK1 (0.58) | POLBMEN1KMT2APADI4LMNA | |
| SCHEMBL9208449 | 0.65 | POLB (0.68) | POLBMEN1KMT2APADI4HDAC6 | |
| SCHEMBL19650682 | 0.65 | HTR6 (0.55) | POLBMEN1KMT2APADI4LMNA | |
| SCHEMBL598819 | 0.65 | ALDH1A1 (0.57) | MEN1KMT2ALMNAGAARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024258-A | Composition of and method for reducing hypertension with a 1-[1-(indol-3-ylethyl)-piperazin-4-yl]-3-substituted urea | AMERICAN HOECHST CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3948918-A | HYPOTENSIVE | AMERICAN HOECHST CORPORATION (US) | 1976-04-06 | — | — | US | disclosed |