Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11678758 | 0.74 | BCHE (0.61) | BCHEHTR7KMT2AMAPTHTT | |
| SCHEMBL11680163 | 0.74 | POLB (0.55) | KMT2AGAAMEN1 | |
| SCHEMBL11680841 | 0.69 | HTR2A (0.57) | ALDH1A1TSHRKMT2ACYP1A2CYP2C19 | |
| SCHEMBL20145432 | 0.69 | BCHE (0.53) | BCHEHTR7KMT2AHTTDRD2 | |
| SCHEMBL11838387 | 0.69 | HDAC1 (0.50) | HTR7ALDH1A1TSHRKMT2AALOX15 | |
| SCHEMBL11415261 | 0.68 | KDM4E (0.56) | BCHEALDH1A1TSHRHPGDALOX15 | |
| SCHEMBL11834250 | 0.68 | DRD2 (0.48) | HTR7ALDH1A1KMT2AHPGDMAPT | |
| SCHEMBL11681786 | 0.67 | KCNH2 (0.46) | HTR7ALDH1A1KMT2AALOX15MAPT | |
| SCHEMBL14193990 | 0.67 | CHRNB2 (0.64) | BCHEALDH1A1TSHRKMT2AHPGD | |
| SCHEMBL11840524 | 0.67 | CYP2D6 (0.51) | HTR7ALDH1A1TSHRALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4024258-A | Composition of and method for reducing hypertension with a 1-[1-(indol-3-ylethyl)-piperazin-4-yl]-3-substituted urea | AMERICAN HOECHST CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3948918-A | HYPOTENSIVE | AMERICAN HOECHST CORPORATION (US) | 1976-04-06 | — | — | US | disclosed |