Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363631 | 0.88 | OPRD1 (0.50) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL29705809 | 0.88 | OPRD1 (0.50) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL3750826 | 0.86 | HTR2C (0.35) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL30508374 | 0.86 | SIGMAR1 (0.46) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11782034 | 0.86 | SIGMAR1 (0.46) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11870107 | 0.86 | SIGMAR1 (0.43) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11853705 | 0.83 | SIGMAR1 (0.49) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11687660 | 0.81 | PRCP (0.49) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11867362 | 0.81 | PRCP (0.50) | PRCPSIGMAR1OPRD1KCNH2 | |
| SCHEMBL11781458 | 0.80 | OPRD1 (0.46) | PRCPSIGMAR1OPRD1KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3959475-A | ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1976-05-25 | — | — | US | claimed |
| US-4024263-A | ANALGESIC, ANTICONVULSANT, ANTIDEPRESSANT | AMERICAN HOECHST CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3996354-A | 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |
| US-3980786-A | 1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s | AMERICAN HOECHST CORPORATION (US) | 1976-09-14 | — | — | US | disclosed |