Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11782034 | 0.85 | SIGMAR1 (0.46) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL30508374 | 0.85 | SIGMAR1 (0.46) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL11843293 | 0.85 | SIGMAR1 (0.44) | SIGMAR1OPRD1KCNH2MAOAKDM1A | |
| SCHEMBL11684159 | 0.85 | SIGMAR1 (0.44) | SIGMAR1OPRD1KCNH2 | |
| SCHEMBL4363631 | 0.85 | OPRD1 (0.50) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL29705809 | 0.85 | OPRD1 (0.50) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL11857141 | 0.84 | SIGMAR1 (0.50) | SIGMAR1PRCPOPRD1KCNH2ADRA2A | |
| SCHEMBL11870107 | 0.83 | SIGMAR1 (0.43) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL11686154 | 0.83 | PRCP (0.43) | SIGMAR1PRCPOPRD1KCNH2 | |
| SCHEMBL11682595 | 0.82 | OPRD1 (0.45) | SIGMAR1PRCPOPRD1KCNH2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3959475-A | ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC | AMERICAN HOECHST CORPORATION (US) | 1976-05-25 | — | — | US | claimed |
| US-3996354-A | 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |