SCHEMBL11686246

SCHEMBL11686246

O=C1NC(=O)C(Cc2cc(O)c(O)c(O)c2)N1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.50
THRB P10828 1/20 0.50
MAOA P21397 2/20 0.40
CISD1 Q9NZ45 2/20 0.40
MAOB P27338 1/20 0.40
CXCR4 P61073 1/20 0.39
GAA P10253 2/20 0.38
ADAMTS5 Q9UNA0 5/20 0.34
ADAMTS4 O75173 2/20 0.34
ADAM17 P78536 2/20 0.34
ADAM10 O14672 1/20 0.34
MMP12 P39900 1/20 0.34
ADAM9 Q13443 1/20 0.34
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CASP1 P29466 1/20 0.33
KMT2A Q03164 1/20 0.33
MMP2 P08253 1/20 0.32
SELL P14151 1/20 0.32
SELP P16109 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29600642 0.83 THRA (0.48) THRATHRBCXCR4GAAMEN1
SCHEMBL1011770 0.83 THRA (0.48) THRATHRBCXCR4GAAMEN1
SCHEMBL28722955 0.77 CXCR4 (0.53) THRATHRBCXCR4GAAHDAC8
SCHEMBL1012031 0.77 CXCR4 (0.53) THRATHRBCXCR4GAAHDAC8
SCHEMBL5062730 0.74 CXCR4 (0.42) THRATHRBCXCR4GAAADAMTS5
SCHEMBL9819566 0.73 SHBG (0.50) THRATHRBGAAMEN1ALDH1A1
SCHEMBL14357764 0.73 HDAC8 (0.57) MAOBCXCR4GAAADAMTS5ADAMTS4
SCHEMBL1011632 0.73 HDAC8 (0.57) MAOBCXCR4GAAADAMTS5ADAMTS4
SCHEMBL11685948 0.72 GAA (0.41) THRATHRBCXCR4GAAADAMTS5
SCHEMBL11683936 0.72 TYR (0.43) THRATHRBCXCR4GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4016037-A FERMENTING A HYDANTOIN COMPOUND WITH FLAVOBACTERIUM AMINOGENES OR ITS ENZYMES AJINOMOTO CO., INC. (JA) 1977-04-05 US disclosed