Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP4 | P49662 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP9 | P55211 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675185 | 0.80 | SNCA (0.48) | SNCALMNAMAPTCASP1CASP3 | |
| SCHEMBL11685197 | 0.77 | SNCA (0.37) | SNCALMNAMAPTKMT2ACASP1 | |
| SCHEMBL11686710 | 0.74 | HTT (0.41) | SNCALMNAMEN1KMT2ACYP1A2 | |
| Iodide SCHEMBL11207200 | 0.72 | LMNA (0.41) | SNCALMNAMAPTMEN1KMT2A | |
| Iodide SCHEMBL9323778 | 0.72 | CYP1A2 (0.40) | LMNAMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL17356869 | 0.72 | SNCA (0.56) | SNCALMNAMAPTMEN1KMT2A | |
| SCHEMBL29039151 | 0.71 | LMNA (0.42) | SNCALMNAMAPTMEN1KMT2A | |
| SCHEMBL28852929 | 0.71 | ALDH1A1 (0.44) | SNCAMAPTMEN1KMT2ACASP1 | |
| SCHEMBL27648580 | 0.70 | ALDH1A1 (0.46) | LMNAMAPTKMT2AALDH1A1GAA | |
| SCHEMBL9304911 | 0.70 | SNCA (0.47) | SNCAMAPTMEN1KMT2ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4025347-A | Fogged direct-positive silver halide emulsion containing a cyanine dye having an indole or indolenine nucleus substituted with a benzoyl or a phenylsulfonyl group | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1977-05-24 | — | — | US | disclosed |