Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11879 | 0.96 | SIGMAR1 (0.42) | SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL11180 | 0.95 | OPRM1 (0.38) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11689 | 0.93 | OPRM1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11880 | 0.89 | SIGMAR1 (0.46) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11181 | 0.88 | OPRM1 (0.42) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL4483 | 0.88 | OPRM1 (0.45) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL4330 | 0.84 | SIGMAR1 (0.47) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL5236 | 0.83 | OPRM1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL10120 | 0.82 | OPRM1 (0.43) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL4086 | 0.79 | ABCC3 (0.46) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |