Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121 | 0.90 | OPRM1 (0.44) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL11879 | 0.82 | SIGMAR1 (0.42) | OPRM1NPSR1OPRD1OPRK1 | |
| SCHEMBL950 | 0.82 | OPRM1 (0.43) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL11688 | 0.82 | SIGMAR1 (0.40) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL11180 | 0.81 | OPRM1 (0.38) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL11510 | 0.80 | ABCC3 (0.40) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL9783 | 0.79 | OPRM1 (0.38) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL10005 | 0.79 | ABCC3 (0.41) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL9550 | 0.77 | OPRM1 (0.37) | OPRM1LMNATSHRNPSR1TDP1 | |
| SCHEMBL10135 | 0.77 | LMNA (0.39) | OPRM1LMNATSHRNPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |