SCHEMBL11697271

SCHEMBL11697271

Nc1cc(N(CCCl)CCCl)ccc1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
RAD52 P43351 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
CYP3A4 P08684 3/20 0.38
HIF1A Q16665 3/20 0.38
MAPT P10636 3/20 0.38
ALOX15 P16050 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NFKB1 P19838 2/20 0.38
THPO P40225 2/20 0.38
LMNA P02545 2/20 0.38
PMP22 Q01453 2/20 0.38
PTGS1 P23219 2/20 0.38
ABCB11 O95342 1/20 0.38
CHRM2 P08172 1/20 0.38
ADRA2A P08913 1/20 0.38
CHRM1 P11229 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9730719 0.81 TDP1 (0.48) ALDH1A1L3MBTL1RAD52SMN1; SMN2CYP3A4
SCHEMBL31696766 0.81 ALDH1A1 (0.41) ALDH1A1L3MBTL1RAD52SMN1; SMN2CYP3A4
SCHEMBL10333910 0.80 ALDH1A1 (0.49) ALDH1A1L3MBTL1RAD52SMN1; SMN2CYP3A4
SCHEMBL11265833 0.80 TYR (0.41) ALDH1A1L3MBTL1RAD52SMN1; SMN2CYP3A4
SCHEMBL16970730 0.74 S100B (0.46) ALDH1A1L3MBTL1RAD52SMN1; SMN2CYP3A4
SCHEMBL9513863 0.73 ALDH1A1 (0.50) ALDH1A1L3MBTL1SMN1; SMN2CYP3A4HIF1A
SCHEMBL3213200 0.73 CYP2A6 (0.47) ALDH1A1L3MBTL1CYP3A4MAPTALOX15
SCHEMBL896520 0.71 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CYP3A4HIF1AMAPT
Hydrochloric Acid SCHEMBL8509062 0.70 ALDH1A1 (0.42) ALDH1A1RAD52SMN1; SMN2CYP3A4HIF1A
SCHEMBL11638889 0.70 ALDH1A1 (0.49) ALDH1A1L3MBTL1SMN1; SMN2CYP3A4HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US claimed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US disclosed