Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GALR2 | O43603 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780918 | 0.92 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL20825815 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL12395547 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL3364332 | 0.86 | RAB9A (0.50) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL5666638 | 0.84 | MAPT (0.53) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL14078329 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL28835926 | 0.81 | MAPT (0.51) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL12812841 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL27474529 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTKMT2APOLBKDM4E | |
| SCHEMBL11695937 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214576-A1 | Topoisomerase Inhibitors and Prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| US-20080214576-A1 | Topoisomerase Inhibitors and Prodrugs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| US-4058607-A | DIHALOVINYL DIALKYL PHOSPHATE, 1,3-BENZODIOXOLES | AIRWICK INDUSTRIES, INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-3962415-A | Insecticide evaporator comprising DDVP with synergized benzodioxole compound as stabilizer | AIRWICK INDUSTRIES, INC. (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214576-A1 | Topoisomerase Inhibitors and Prodrugs | TOP2A, TOP1, TOP2B | ALDH1A1 2978/4885MAPT 2510/4885KMT2A 2081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.