Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenformin SCHEMBL11691594 | 1.00 | MEN1 (0.47) | MEN1TSHRKMT2ACA12CA2 | |
| Phenformin SCHEMBL8424 | 0.89 | NPC1 (0.52) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL12487086 | 0.89 | NPC1 (0.52) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL3487197 | 0.88 | NPC1 (0.50) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL210008 | 0.88 | NPC1 (0.50) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL15669213 | 0.88 | NPC1 (0.50) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL1560339 | 0.88 | RAB9A (0.50) | TSHRCA12CA2CA9EPHX1 | |
| SCHEMBL18624768 | 0.86 | NPC1 (0.49) | TSHRCA12CA2CA9EPHX1 | |
| Phenformin SCHEMBL28415756 | 0.85 | ALDH1A1 (0.57) | CA12CA2CA9EPHX1NPC1 | |
| SCHEMBL3679691 | 0.83 | CA12 (0.53) | CA12CA2CA9EPHX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4028402-A | HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-06-07 | — | — | US | disclosed |