Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.73 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12601193 | 0.89 | NOX1 (0.64) | NOX1NT5EALOX5MAPK13MAPK12 | |
| SCHEMBL1170234 | 0.88 | NOX1 (0.62) | NOX1NT5EALOX5MAPK13MAPK12 | |
| SCHEMBL1071183 | 0.85 | NOX1 (1.00) | NOX1ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL14023495 | 0.83 | MAPK14 (0.63) | NT5EALOX5ESR1ESR2MAPK13 | |
| SCHEMBL1170565 | 0.82 | NOX1 (0.56) | NOX1NT5EALOX5MAPK13MAPK12 | |
| SCHEMBL14023509 | 0.80 | NT5E (0.58) | NOX1NT5EESR1ESR2MAPK13 | |
| SCHEMBL12561659 | 0.80 | NT5E (0.58) | NOX1NT5EESR1ESR2MAPK13 | |
| SCHEMBL12561573 | 0.80 | KDM4E (0.60) | NOX1NT5EESR1ESR2MAPK13 | |
| SCHEMBL12561595 | 0.79 | NOX1 (0.52) | NOX1NT5EALOX5KDM4EMAPT | |
| SCHEMBL12152229 | 0.79 | NOX1 (0.76) | NOX1ALOX5MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | claimed |
| EP-1531674-B1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC (CA) | 2014-06-18 | — | — | EP | claimed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | claimed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | claimed |
| EP-1531674-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | Lorus Therapeutics Inc. (CA) | 2005-05-25 | — | — | EP | claimed |
| WO-2004016086-A2 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2004-02-26 | — | — | WO | claimed |
| US-4721670-A | Analytical reagent, analytical method, and multilayer chemical-analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1988-01-26 | — | — | US | claimed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| EP-0256562-B1 | Dry-type multilayer analytical element | FUJI PHOTO FILM CO LTD (JP) | 1994-04-06 | — | — | EP | disclosed |
| EP-0272578-B1 | MULTILAYER ANALYSIS ELEMENTS FOR THE DETERMINATION OF TOTAL CHOLESTEROL | Fuji Photo Film Co., Ltd. (JP) | 1993-03-24 | — | — | EP | disclosed |
| US-5004685-A | Support with chromogen, peroxidatively active material, oxidase, ferrocyanide; measures amount of hydrogen peroxide produced by analyte | FUJI PHOTO FILM CO., LTD. (JP) | 1991-04-02 | — | — | US | disclosed |
| EP-0165588-B1 | ANALYTICAL REAGENT, ANALYTICAL METHOD, AND MULTILAYER CHEMICAL-ANALYTICAL ELEMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1990-05-02 | — | — | EP | disclosed |
| EP-0272578-A2 | Multilayer analysis elements for the determination of total cholesterol | Fuji Photo Film Co., Ltd. (JP) | 1988-06-29 | — | — | EP | disclosed |
| EP-0244825-A1 | Dry-type analytical element for cholesterol | FUJI PHOTO FILM CO., LTD. (JP) | 1987-11-11 | — | — | EP | disclosed |
| EP-0165588-A2 | Analytical reagent, analytical method, and multilayer chemical-analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1985-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NOX1 140/4885NT5E 161/4885ALOX5 748/4885 |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NOX1 140/4885NT5E 161/4885ALOX5 748/4885 |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | IDO2, ERG28, IL4 | NOX1 140/4885NT5E 161/4885ALOX5 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.