Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170149 | 0.82 | NOX1 (0.73) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL12601193 | 0.79 | NOX1 (0.64) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL1170234 | 0.78 | NOX1 (0.62) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL1071183 | 0.73 | NOX1 (1.00) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL5570317 | 0.71 | NT5E (0.47) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL12561595 | 0.71 | NOX1 (0.52) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL8797410 | 0.70 | NOX1 (0.72) | NOX1ALOX5KDM4EKMT2AALDH1A1 | |
| SCHEMBL1170563 | 0.70 | NT5E (0.74) | NOX1ALOX5KDM4EKMT2AGAA | |
| SCHEMBL12561659 | 0.69 | NT5E (0.58) | NOX1KDM4EKMT2AALDH1A1GLA | |
| SCHEMBL14023509 | 0.69 | NT5E (0.58) | NOX1KDM4EKMT2AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | claimed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | claimed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | claimed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NOX1 140/4885ALOX5 748/4885KDM4E 745/4885 |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | NOX1 140/4885ALOX5 748/4885KDM4E 745/4885 |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | IDO2, ERG28, IL4 | NOX1 140/4885ALOX5 748/4885KDM4E 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.