SCHEMBL11706409

SCHEMBL11706409

CCOC(=O)C=CC1(c2cccc(OCC)c2)CCC(=O)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ALOX5 P09917 2/20 0.40
BACE1 P56817 2/20 0.38
TET3 O43151 1/20 0.38
FBXL19 Q6PCT2 1/20 0.38
CXXC5 Q7LFL8 1/20 0.38
TET1 Q8NFU7 1/20 0.38
KDM2B Q8NHM5 1/20 0.38
CXXC4 Q9H2H0 1/20 0.38
KDM2A Q9Y2K7 1/20 0.38
KCNA3 P22001 1/20 0.38
DDB1 Q16531 1/20 0.37
CRBN Q96SW2 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TP53 P04637 1/20 0.36
MAPT P10636 4/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11704944 0.87 BACE1 (0.40) KMT2AALDH1A1BACE1KCNA3L3MBTL1
SCHEMBL11704583 0.84 L3MBTL1 (0.47) KMT2AALDH1A1KCNA3L3MBTL1MAPT
SCHEMBL11706457 0.82 ALOX5 (0.45) KMT2AALDH1A1KDM4ESMN1; SMN2ALOX5
SCHEMBL8486156 0.75 L3MBTL1 (0.52) KMT2AALDH1A1BACE1L3MBTL1MAPT
SCHEMBL8486160 0.75 L3MBTL1 (0.52) KMT2AALDH1A1BACE1L3MBTL1MAPT
SCHEMBL8003754 0.74 ALOX5 (0.46) KMT2AALDH1A1KDM4ESMN1; SMN2ALOX5
SCHEMBL11708270 0.73 ALDH1A1 (0.39) ALDH1A1KDM4ESMN1; SMN2ALOX5L3MBTL1
SCHEMBL8484168 0.72 L3MBTL1 (0.50) KMT2AALDH1A1SMN1; SMN2L3MBTL1MAPT
SCHEMBL8484165 0.72 L3MBTL1 (0.50) KMT2AALDH1A1SMN1; SMN2L3MBTL1MAPT
SCHEMBL11706414 0.72 KMT2A (0.50) KMT2AALDH1A1KDM4ESMN1; SMN2ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4025558-A SPIRO(CYCLOHEXANE-1,1*(2'H)-NAPHTHALENE); BENZOSPIRAN DERIVATIVES; CNS DEPRESSANTS, LOWERS BLOOD PRESSURE THE UPJOHN COMPANY (US) 1977-05-24 US disclosed
US-4010201-A AMINOBENZOSPIRANS, CENTRAL NERVOUS SYSTEM DEPRESSANT, HYPOTENSIVE THE UPJOHN COMPANY (US) 1977-03-01 US disclosed
US-3932425-A CNS DEPRESSANT, BLOOD PRESSURE LOWERING THE UPJOHN COMPANY (US) 1976-01-13 US disclosed