SCHEMBL8486160

SCHEMBL8486160

CCOC(=O)C=CC1(c2ccccc2)CC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.52
OPRM1 P35372 5/20 0.48
MAPT P10636 5/20 0.47
OPRD1 P41143 3/20 0.47
OPRK1 P41145 3/20 0.47
SLC22A1 O15245 1/20 0.47
SLC6A4 P31645 1/20 0.47
ADRA1A P35348 1/20 0.47
KCNH2 Q12809 1/20 0.47
LMNA P02545 3/20 0.45
MDM2 Q00987 2/20 0.45
MDM4 O15151 1/20 0.45
HCAR2 Q8TDS4 1/20 0.44
ALDH1A1 P00352 2/20 0.44
THRB P10828 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8486156 1.00 L3MBTL1 (0.52) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL8484168 0.94 L3MBTL1 (0.50) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL8484165 0.94 L3MBTL1 (0.50) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL8486337 0.93 L3MBTL1 (0.49) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL8486339 0.93 L3MBTL1 (0.49) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL11704583 0.90 L3MBTL1 (0.47) L3MBTL1OPRM1MAPTOPRD1OPRK1
SCHEMBL6911073 0.82 TSHR (0.47) L3MBTL1OPRM1OPRD1OPRK1SLC22A1
SCHEMBL12000497 0.79 OPRM1 (0.45) L3MBTL1OPRM1MAPTSLC6A4LMNA
SCHEMBL31650308 0.79 LMNA (0.45) L3MBTL1MAPTLMNAALDH1A1CA12
SCHEMBL2437925 0.78 OPRM1 (0.46) OPRM1MAPTOPRK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999015524-A1 THIAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-04-01 WO disclosed