Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 8/20 | 0.44 |
| ▸ | MAOB | P27338 | 8/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22492388 | 0.75 | MAOA (0.45) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL29908277 | 0.71 | PARP10 (0.51) | GRM5 | |
| SCHEMBL21220902 | 0.71 | BMPR1B (0.44) | CREBBPBRD4 | |
| SCHEMBL8284440 | 0.71 | MEN1 (0.69) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL4851604 | 0.69 | MEN1 (0.47) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL3454654 | 0.69 | MEN1 (0.73) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL1275258 | 0.68 | MEN1 (0.55) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL20095715 | 0.68 | BMPR1B (0.41) | CREBBPBRD4 | |
| SCHEMBL25945154 | 0.67 | MEN1 (0.70) | MEN1KMT2AMAPK1NPSR1MAOA | |
| SCHEMBL30029603 | 0.67 | HTR3A (0.42) | MEN1KMT2AMAOAMAOBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4053476-A | 7-AZA-6-ALKOXY-1-TETRALONES | G. D. SEARLE & CO. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4012391-A | 11β-Alkyl-2-azaestratrienes and intermediates | G. D. SEARLE & CO. (US) | 1977-03-15 | — | — | US | disclosed |
| US-4007194-A | Process and intermediates for manufacture of 2-azasterioids | G. D. SEARLE & CO. (US) | 1977-02-08 | — | — | US | disclosed |