Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9318876 | 0.82 | EGLN1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8414880 | 0.81 | EGLN1 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL117096 | 0.76 | ALDH1A1 (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27401575 | 0.75 | P4HTM (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29840564 | 0.74 | LCK (0.56) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL214090 | 0.74 | LCK (0.56) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3127626 | 0.74 | NPC1 (0.46) | MAPTNPC1EGLN1 | |
| SCHEMBL28229449 | 0.73 | EGLN1 (0.48) | MAPTEGLN1KMT2A | |
| Hydrochloric Acid SCHEMBL27800514 | 0.73 | LCK (0.55) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5805411 | 0.72 | MAPT (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424532-A1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | Queen Mary and Westfield College (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125343-A1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2010-11-04 | — | — | WO | disclosed |