SCHEMBL117240

SCHEMBL117240

O=C(Cl)Oc1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL516304 0.77 CA1 (0.36) CA1CA2CA9HSD17B10
SCHEMBL34317 0.77 CA1 (0.36) CA1CA2CA9HSD17B10
SCHEMBL27532940 0.75 CES2 (0.32) CES2CES1
SCHEMBL9800762 0.75
SCHEMBL16814869 0.74 CA1 (0.35) CA1CA2CA9HSD17B10
SCHEMBL570928 0.74 PREP (0.39) CA1CA2CA9HSD17B10
SCHEMBL18697361 0.74 CA1 (0.35) CA1CA2CA9CES2CES1
SCHEMBL176317 0.74 CA1 (0.35) CA1CA2CA9HSD17B10
SCHEMBL1256979 0.74 CA1 (0.31) CA1CA2CA9CES2CES1
SCHEMBL1589344 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4692166-A1 METHOD FOR PRODUCING ACTIVATED POLYETHYLENE GLYCOL DERIVATIVE NOF Corporation (JP) 2026-02-11 EP claimed
WO-2024203596-A1 METHOD FOR PRODUCING ACTIVATED POLYETHYLENE GLYCOL DERIVATIVE 日油株式会社 2024-10-03 WO claimed
US-20210130546-A1 METHODS FOR PREPARING POLYMERIC REAGENTS AND COMPOSITIONS OF POLYMERIC REAGENTS NEKTAR THERAPEUTICS (US) 2021-05-06 US claimed
EP-1922350-B1 METHODS FOR PREPARING POLYMERIC REAGENTS NEKTAR THERAPEUTICS (US) 2015-01-07 EP claimed
US-20140088298-A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2014-03-27 US claimed
US-20140073778-A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2014-03-13 US claimed
US-20130211060-A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2013-08-15 US claimed
US-20130184454-A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2013-07-18 US claimed
US-8445734-B2 Photolabile protective groups for improved processes to prepare oligonucleotide arrays NIGU CHEMIE GMBH (DE) 2013-05-21 US claimed
EP-2590680-A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION Fresenius Kabi Deutschland GmbH (DE) 2013-05-15 EP claimed
WO-2007016560-A2 METHODS FOR PREPARING CARBONATE ESTERS OF POLY(ETYLENE GLYCOL) NEKTAR THERAPEUTICS AL, CORPORATION (US) 2007-02-08 WO claimed
US-20030144499-A1 Photocleavable protecting groups and methods for their use AFFYMETRIX, INC. (US) 2003-07-31 US claimed
US-6147205-A ARYLALKYLOXYCARBONYL GROUPS; FOR SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES AND POLYPEPTIDES AFFYMETRIX, INC. (US) 2000-11-14 US claimed
WO-1998039348-A9 PHOTOCLEAVABLE PROTECTING GROUPS AND METHODS FOR THEIR USE 1999-02-18 WO claimed
WO-1998039348-A1 PHOTOCLEAVABLE PROTECTING GROUPS AND METHODS FOR THEIR USE AFFYMETRIX, INC. (US) 1998-09-11 WO claimed
EP-0290313-B1 PROCESS FOR OBTAINING ACTIVATED NITROSOCARBAMATES SANOFI (FR) 1992-03-04 EP claimed
US-4883903-A FROM CHLOROETHYLAMINE, A HALOFORMATE; AND NITROSYL SULFURIC ACID SANOFI (FR) 1989-11-28 US claimed
EP-0038357-A4 HYDROLYTIC ENZYME-ACTIVATIBLE PRO-DRUGS. UNIV ILLINOIS (US) 1982-03-22 EP claimed
EP-0038357-A1 HYDROLYTIC ENZYME-ACTIVATIBLE PRO-DRUGS University of Illinois Foundation (US) 1981-10-28 EP claimed
WO-1981001145-A1 HYDROLYTIC ENZYME-ACTIVATIBLE PRO-DRUGS UNIV ILLINOIS (US) 1981-04-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210130546-A1 METHODS FOR PREPARING POLYMERIC REAGENTS AND COMPOSITIONS OF POLYMERIC REAGENTS SI, PHYKPL, PHOSPHO1 CA1 24/4885CA2 102/4885CA9 27/4885
US-20140088298-A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION HACL2, HASPIN, LIPA CA1 4165/4885CA2 3932/4885CA9 1051/4885
US-20130211060-A1 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION HACL2, HASPIN, LIPA CA1 4165/4885CA2 3932/4885CA9 1051/4885
US-20030144499-A1 Photocleavable protecting groups and methods for their use RTCB, RRS1, GAR1 CA1 3082/4885CA2 3886/4885CA9 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.