Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519794 | 0.84 | NPC1 (0.40) | NPC1RAB9ACA1CA9 | |
| SCHEMBL11737370 | 0.79 | KMT2A (0.39) | PKMCA1CA9 | |
| SCHEMBL11730921 | 0.77 | ALDH1A1 (0.37) | — | |
| SCHEMBL7525016 | 0.72 | KMT2A (0.38) | NPC1RAB9ACA1CA9 | |
| SCHEMBL7524839 | 0.71 | L3MBTL1 (0.39) | — | |
| SCHEMBL11571870 | 0.69 | NPC1 (0.38) | NPC1PKMRAB9AANO1 | |
| SCHEMBL11731624 | 0.68 | KDM4E (0.32) | CA1CA9 | |
| SCHEMBL7518491 | 0.67 | MAOA (0.50) | NPC1RAB9ACA1CA9 | |
| SCHEMBL7521385 | 0.67 | MAPT (0.54) | NPC1RAB9ACA1CA9 | |
| SCHEMBL7521744 | 0.67 | RAB9A (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001425-A | METHODS OF TREATING HYPERTENSION AND PHARMACEUTICAL COMPOSITIONS COMPRISING 1-TERTIARY-ALKYL-3-(SUBSTITUTED FURYL)UREAS AS ANTIHYPERTENSIVE AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-01-04 | — | — | US | claimed |
| US-3969370-A | 1-Tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-07-13 | — | — | US | claimed |
| US-4001425-A | METHODS OF TREATING HYPERTENSION AND PHARMACEUTICAL COMPOSITIONS COMPRISING 1-TERTIARY-ALKYL-3-(SUBSTITUTED FURYL)UREAS AS ANTIHYPERTENSIVE AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3969370-A | 1-Tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-07-13 | — | — | US | disclosed |