Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11859455 | 0.86 | DRD2 (0.61) | DRD2SIGMAR1SLC18A3MEN1KMT2A | |
| SCHEMBL11867723 | 0.82 | SIGMAR1 (0.61) | DRD2SIGMAR1SLC18A3HTR2AHTR2C | |
| SCHEMBL11730973 | 0.74 | SIGMAR1 (0.45) | SIGMAR1ADRA2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11833942 | 0.73 | DRD2 (0.63) | DRD2SIGMAR1SLC18A3HTR2AHTR2C | |
| SCHEMBL7431676 | 0.73 | SIGMAR1 (0.67) | DRD2SIGMAR1SLC18A3HTR2AHTR2C | |
| SCHEMBL11853407 | 0.73 | SIGMAR1 (0.56) | DRD2SIGMAR1HTR1AKMT2AKCNH2 | |
| Ethylene SCHEMBL11195411 | 0.72 | DRD2 (0.55) | DRD2SIGMAR1SLC18A3HTR2AHTR2C | |
| SCHEMBL10992610 | 0.72 | DRD2 (0.61) | DRD2SIGMAR1SLC18A3MEN1KMT2A | |
| SCHEMBL3254880 | 0.71 | DRD2 (1.00) | DRD2SIGMAR1SLC18A3HTR2AHTR2C | |
| Ethylene SCHEMBL11191814 | 0.71 | DRD2 (0.56) | DRD2SIGMAR1SLC18A3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031224-A | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | claimed |
| US-4031224-A | 1,3-Dihydro-heteroarylspiro (isobenzofuran)s | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |