Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.60 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.60 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.60 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.60 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.60 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.60 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.60 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.60 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.60 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | LTA4H | P09960 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | EBP | Q15125 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1405290 | 0.98 | CYP2D6 (0.74) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL12610941 | 0.98 | CYP2D6 (0.74) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL10505479 | 0.96 | CYP2D6 (0.72) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL6676718 | 0.88 | LTA4H (0.62) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL9706125 | 0.87 | EBP (0.72) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL21195812 | 0.85 | KCNA3 (0.64) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL22224170 | 0.85 | ALDH1A1 (0.63) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| Methylamine SCHEMBL10666826 | 0.85 | LTA4H (0.58) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL14463907 | 0.84 | LTA4H (0.57) | CYP2D6HTTLTA4HCYP1A2CYP2C9 | |
| SCHEMBL9706141 | 0.84 | KDM4E (0.73) | CYP2D6HTTLTA4HCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258328-B2 | Method and intermediates for preparing 19-norsteroid compounds | AVENTIS PHARMA S.A. (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20110046402-A1 | NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS | AVENTIS PHARMA S.A. (FR) | 2011-02-24 | — | — | US | disclosed |
| US-20040229853-A1 | Novel method and intermediates for preparing 19-norsteroid compounds | AVENTIS PHARMA S.A. (FR) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229853-A1 | Novel method and intermediates for preparing 19-norsteroid compounds | CYP17A1, HSD17B7, CYP11B1 | SIGMAR1 1097/4885CHRM2 3034/4885ADRA2A 571/4885 |
| US-20110046402-A1 | NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS | HSD17B7, CYP17A1, HSD17B13 | SIGMAR1 1037/4885CHRM2 1624/4885ADRA2A 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.