Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.48 |
| ▸ | HTR1B | P28222 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11735738 | 0.84 | HTR2A (0.56) | HTR1AHTR2A | |
| SCHEMBL11738116 | 0.84 | HTR6 (0.56) | HTR1DHTR1BKDM4EMAPTTRPM8 | |
| SCHEMBL11739332 | 0.76 | HTR2A (0.69) | HTR1BHTR1AHTR2A | |
| SCHEMBL11739126 | 0.75 | HTR2A (0.60) | HTR1AHTR2A | |
| SCHEMBL11734250 | 0.75 | HTR2A (0.65) | HTR1AHTR2ABCHE | |
| SCHEMBL11739008 | 0.74 | MPO (0.57) | HTR1AHTR2AHTR6KCNH2 | |
| SCHEMBL32669329 | 0.73 | TRPM8 (0.67) | HTR1DHTR1BHTR1AHTR2AKDM4E | |
| SCHEMBL8746190 | 0.71 | TRPM8 (0.79) | HTR1DHTR1BHTR1AMTNR1AMTNR1B | |
| SCHEMBL11733974 | 0.71 | HTR2A (0.60) | HTR1AHTR2ABCHEACHE | |
| SCHEMBL11739185 | 0.71 | HTR2A (0.60) | HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4031221-A | ANALGESICS, TRANQUILIZERS, INDOLE COMPOUNDS | AMERICAN HOECHST CORPORATION (US) | 1977-06-21 | — | — | US | disclosed |