Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | NPC1 | O15118 | 3/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.76 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.76 |
| ▸ | RELA | Q04206 | 1/20 | 0.76 |
| ▸ | ATM | Q13315 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | DHODH | Q02127 | 6/20 | 0.75 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199980 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| SCHEMBL4601802 | 0.86 | KDM4E (1.00) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| SCHEMBL29536364 | 0.86 | DHODH (1.00) | SMN1; SMN2KDM4ELMNADHODHPDE10A | |
| SCHEMBL2467110 | 0.86 | DHODH (1.00) | SMN1; SMN2KDM4ELMNADHODHPDE10A | |
| Cinchophen SCHEMBL25519 | 0.85 | KDM4E (1.00) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| Cinchophen SCHEMBL29376617 | 0.85 | KDM4E (1.00) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| Cinchophen SCHEMBL7588217 | 0.85 | KDM4E (1.00) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| Cinchophen SCHEMBL4464779 | 0.84 | KDM4E (0.97) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| Cinchophen SCHEMBL10757475 | 0.84 | KDM4E (0.97) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| Cinchophen SCHEMBL4805149 | 0.84 | KDM4E (0.97) | SMN1; SMN2KDM4ELMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | AARS1, GARS1, TRMT1 | SMN1; SMN2 3128/4885KDM4E 1144/4885LMNA 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.