Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | TRHR | P34981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11733472 | 0.88 | HDAC3 (0.47) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL31061201 | 0.84 | OPRK1 (0.45) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL28864215 | 0.82 | TRHR (0.42) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL19359174 | 0.82 | TRHR (0.42) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL10359347 | 0.82 | TRHR (0.42) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL11172998 | 0.81 | HDAC3 (0.41) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL7417306 | 0.81 | TRHR (0.64) | TRHR | |
| SCHEMBL11164182 | 0.80 | HDAC3 (0.41) | HDAC3HDAC11HDAC6HDAC1HDAC2 | |
| SCHEMBL2197324 | 0.80 | TRHR (0.56) | TRHR | |
| SCHEMBL2190498 | 0.80 | CNR1 (0.41) | HDAC3HDAC11HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4053588-A | PYROGLUTAMIC ACID AMIDES | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-10-11 | — | — | US | disclosed |