Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | TSPO | P30536 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11749033 | 0.77 | PTGES (0.43) | PTGESMAPTPTGS2LMNAALDH1A1 | |
| SCHEMBL11742036 | 0.76 | PTGES (0.38) | PTGESMAPTLMNAALDH1A1TP53 | |
| SCHEMBL11745285 | 0.75 | NPSR1 (0.44) | PTGESMAPTPTGS2TP53 | |
| SCHEMBL11749040 | 0.74 | PTGES (0.46) | PTGESMAPTPTGS2LMNAALDH1A1 | |
| SCHEMBL11747976 | 0.73 | PTGES (0.43) | PTGESMAPTLMNAALDH1A1TP53 | |
| SCHEMBL11747384 | 0.73 | PRMT1 (0.36) | PTGESMAPT | |
| SCHEMBL11744427 | 0.72 | PTGES (0.42) | PTGESMAPTLMNAALDH1A1TP53 | |
| SCHEMBL11749644 | 0.72 | ALDH1A1 (0.44) | PTGESMAPTPTGS2LMNAALDH1A1 | |
| SCHEMBL11744357 | 0.71 | CACNA2D1 (0.40) | PTGESMAPTPTGS2LMNATP53 | |
| SCHEMBL11745628 | 0.70 | ALDH1A1 (0.45) | PTGESMAPTPTGS2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |