Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11749033 | 0.78 | PTGES (0.43) | MAPTPTGS2PTGESTP53LMNA | |
| SCHEMBL11749370 | 0.75 | SCN9A (0.41) | MAPTPTGS2PTGES | |
| SCHEMBL11751925 | 0.74 | CACNA2D1 (0.47) | CACNA2D1MAPTPTGS2TP53LMNA | |
| SCHEMBL11750266 | 0.73 | CACNA2D1 (0.46) | CACNA2D1MAPTPTGS2TP53LMNA | |
| SCHEMBL11747976 | 0.72 | PTGES (0.43) | MAPTPTGESTP53LMNA | |
| SCHEMBL11751106 | 0.72 | TP53 (0.45) | CACNA2D1MAPTTP53LMNA | |
| SCHEMBL11745628 | 0.72 | ALDH1A1 (0.45) | MAPTPTGS2PTGESLMNA | |
| SCHEMBL11744427 | 0.71 | PTGES (0.42) | MAPTPTGESTP53LMNA | |
| SCHEMBL11749644 | 0.71 | ALDH1A1 (0.44) | MAPTPTGS2PTGESTP53LMNA | |
| SCHEMBL11742591 | 0.71 | PTGES (0.42) | MAPTPTGS2PTGESTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008232-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3979516-A | Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3948894-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1976-04-06 | — | — | US | disclosed |