Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754171 | 1.00 | MAPT (0.47) | MAPTKDM4ELMNAMAPK1XBP1 | |
| SCHEMBL11753660 | 0.96 | MAPT (0.50) | MAPTKDM4ELMNAMAPK1XBP1 | |
| SCHEMBL11042394 | 0.92 | PTGS2 (0.49) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL10801295 | 0.82 | ALDH1A1 (0.54) | MAPTKDM4ELMNAPTGS2PTGS1 | |
| SCHEMBL11041561 | 0.82 | PTGDR2 (0.45) | KDM4ESMN1; SMN2PTGS2PTGS1ALDH1A1 | |
| SCHEMBL11754131 | 0.80 | L3MBTL1 (0.49) | MAPTKDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL11751365 | 0.80 | L3MBTL1 (0.49) | MAPTKDM4ELMNAMAPK1MEN1 | |
| SCHEMBL11750815 | 0.80 | ALDH1A1 (0.50) | MAPTKDM4EMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL5732537 | 0.79 | XIAP (0.53) | MAPTKDM4EXIAPPTGS2PTGS1 | |
| SCHEMBL11751717 | 0.77 | DHODH (0.43) | MAPTKDM4ELMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | claimed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | claimed |
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |