Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061148 | 0.77 | SIGMAR1 (0.56) | SIGMAR1HTR1AADRA1ATAAR1SLC18A2 | |
| SCHEMBL20061130 | 0.77 | SIGMAR1 (0.56) | SIGMAR1HTR1AADRA1ATAAR1SLC18A2 | |
| SCHEMBL11779507 | 0.76 | ALDH1A1 (0.39) | SIGMAR1ACACBALDH1A1THRBRAB9A | |
| SCHEMBL8400677 | 0.68 | ALDH1A1 (0.55) | ALDH1A1THRB | |
| SCHEMBL8400676 | 0.68 | ALDH1A1 (0.55) | ALDH1A1THRB | |
| SCHEMBL10426988 | 0.67 | ALDH1A1 (0.40) | HTR1AADRA1DADRA1AADRA1BKDM1A | |
| SCHEMBL10426989 | 0.67 | ALDH1A1 (0.40) | HTR1AADRA1DADRA1AADRA1BKDM1A | |
| SCHEMBL10426990 | 0.67 | ALDH1A1 (0.40) | HTR1AADRA1DADRA1AADRA1BKDM1A | |
| SCHEMBL20995905 | 0.66 | ALDH1A1 (0.50) | ALDH1A1THRB | |
| SCHEMBL1496787 | 0.66 | NPY1R (0.57) | ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4008329-A | ANTIDEPRESSANT | SOCIETE ANONYME DITE: CENTRE EUROPEN DE RECHERCHES MAUVERNAY (C.E.R.M.) (FR) | 1977-02-15 | — | — | US | claimed |