Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11748298 | 0.85 | CACNA1D (0.69) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11748826 | 0.82 | CACNA1B (0.52) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL1672208 | 0.82 | TSHR (0.70) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11827679 | 0.82 | CYP1A2 (0.77) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11754353 | 0.81 | CACNA1C (0.43) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL10733629 | 0.80 | CACNA1F (0.76) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11447102 | 0.80 | TSHR (0.57) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11742384 | 0.80 | ADORA3 (0.57) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL4608919 | 0.80 | CACNA1C (0.64) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S | |
| SCHEMBL11749142 | 0.80 | NPSR1 (0.51) | TSHRCACNA1CCACNA1DCACNA1FCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4048171-A | 1,4-Dihydropyridines | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-13 | — | — | US | claimed |
| US-4048171-A | 1,4-Dihydropyridines | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-13 | — | — | US | disclosed |