Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11759533 | 0.86 | MAPT (0.45) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL13047036 | 0.85 | ALDH1A1 (0.45) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL11761539 | 0.82 | KDM4E (0.44) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL13049324 | 0.77 | LMNA (0.43) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL11758661 | 0.75 | METAP2 (0.48) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL11761271 | 0.74 | MAPT (0.58) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL11759226 | 0.73 | RHEB (0.45) | HPGDALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL11756830 | 0.73 | SLC6A9 (0.51) | SLC6A9 | |
| SCHEMBL8367844 | 0.73 | ALDH1A1 (0.49) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL27661827 | 0.73 | KDM4E (0.49) | HPGDALDH1A1MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4044010-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3954764-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |