Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11766425 | 1.00 | HTR1A (0.45) | HTR1APRCPPLAU | |
| SCHEMBL10763815 | 0.98 | HTR1A (0.46) | HTR1APRCPPLAU | |
| SCHEMBL4107085 | 0.98 | HTR1A (0.46) | HTR1APRCPPLAU | |
| SCHEMBL4107088 | 0.98 | HTR1A (0.46) | HTR1APRCPPLAU | |
| SCHEMBL4107087 | 0.98 | HTR1A (0.46) | HTR1APRCPPLAU | |
| SCHEMBL8095868 | 0.86 | HTR1A (0.57) | HTR1APRCPPLAU | |
| SCHEMBL8172568 | 0.86 | HTR1A (0.57) | HTR1APRCPPLAU | |
| SCHEMBL26725468 | 0.85 | MBTD1 (0.42) | HTR1APRCP | |
| SCHEMBL20833280 | 0.85 | MBTD1 (0.42) | HTR1APRCP | |
| Bromide SCHEMBL11763695 | 0.80 | SIGMAR1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4022792-A | ANALGESICS | STERLING DRUG INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-3976653-A | ANALGESIC ANTAGONIST | STERLING DRUG INC. (US) | 1976-08-24 | — | — | US | disclosed |