Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177227 | 0.91 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Hydrochloric Acid SCHEMBL1177668 | 0.90 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Bromide SCHEMBL1177354 | 0.90 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Acetic Acid SCHEMBL27674816 | 0.87 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Phosphoric Acid SCHEMBL1177230 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNARAB9A | |
| Phosphonic Acid SCHEMBL27654802 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Sulfuric Acid SCHEMBL1177401 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Chloroacetic Acid SCHEMBL19182725 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| SCHEMBL1177875 | 0.83 | LMNA (0.51) | ALDH1A1MAPK1L3MBTL1LMNANOTUM | |
| Dichloroacetic Acid SCHEMBL19182790 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPK1L3MBTL1LMNANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308830-B1 | ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES | PHOTOCURE ASA (NO) | 2017-06-14 | — | — | EP | disclosed |
| US-8692014-B2 | Acid addition salts of 5-aminolevulinic acid or its derivatives | PHOTOCURE ASA (NO) | 2014-04-08 | — | — | US | disclosed |
| CN-1938264-B | Acid addition salts of 5-aminolevulinic acid or derivatives thereof | PHOTOCURE ASA | 2012-05-23 | — | — | CN | disclosed |
| US-20110125012-A1 | ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES | BRAENDEN JON ERIK | 2011-05-26 | — | — | US | disclosed |
| EP-2308830-A1 | Acid addition salts of 5-aminolevulinic acid or its derivatives | Photocure ASA (NO) | 2011-04-13 | — | — | EP | disclosed |
| US-7888526-B2 | Nonhygroscopic photosensitizing agents; sulphonate, hydrobromide, sulfate, nitrate and/or phosphate derivatives; diagnosing skin disorders | PHOTOCURE ASA (NO) | 2011-02-15 | — | — | US | disclosed |
| US-20080064752-A1 | Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives | PHOTOCURE ASA (NO) | 2008-03-13 | — | — | US | disclosed |
| CN-1938264-A | Acid addition salts of 5-aminolevulinic acid or derivatives thereof | PHOTOCURE ASA (NO) | 2007-03-28 | — | — | CN | disclosed |
| EP-1727786-A1 | ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES | Photocure ASA (NO) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005092838-A1 | ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES | PHOTOCURE ASA (NO) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064752-A1 | Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives | ALAD, AASDHPPT, ABAT | ALDH1A1 793/4885MAPK1 1719/4885L3MBTL1 2982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.