Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | PRCP | P42785 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11778618 | 0.93 | OPRD1 (0.43) | OPRD1KCNH2SIGMAR1 | |
| SCHEMBL11781143 | 0.93 | SIGMAR1 (0.51) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11778772 | 0.88 | OPRD1 (0.47) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11780509 | 0.84 | SIGMAR1 (0.45) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11781464 | 0.84 | OPRD1 (0.45) | OPRD1KCNH2SIGMAR1PRCPADRA2A | |
| SCHEMBL11781772 | 0.84 | PRCP (0.52) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11863710 | 0.83 | SIGMAR1 (0.60) | OPRD1SIGMAR1OPRM1OPRK1ADRA2A | |
| SCHEMBL11859408 | 0.82 | OPRD1 (0.47) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11783971 | 0.82 | PRCP (0.48) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11849041 | 0.80 | OPRD1 (0.46) | OPRD1KCNH2SIGMAR1PRCPOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3980786-A | 1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s | AMERICAN HOECHST CORPORATION (US) | 1976-09-14 | — | — | US | claimed |
| US-3980786-A | 1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s | AMERICAN HOECHST CORPORATION (US) | 1976-09-14 | — | — | US | disclosed |