Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 10/20 | 0.62 |
| ▸ | DRD2 | P14416 | 10/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11785343 | 0.90 | DRD2 (0.62) | HTR6HTR1ADRD2HTR2AACHE | |
| SCHEMBL11637132 | 0.85 | HTR6 (0.78) | HTR6HTR1ADRD2HTR2AACHE | |
| SCHEMBL11315770 | 0.84 | HTR6 (0.64) | HTR6HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11639446 | 0.84 | HTR6 (0.76) | HTR6HTR1ADRD2HTR2AACHE | |
| Hydrochloric Acid SCHEMBL11318655 | 0.83 | HTR6 (0.62) | HTR6HTR1ADRD2 | |
| SCHEMBL11786344 | 0.80 | HTR1A (0.85) | HTR1ADRD2HTR2A | |
| SCHEMBL4194997 | 0.76 | HTR1A (1.00) | HTR1ADRD2HTR2AACHE | |
| SCHEMBL238334 | 0.76 | MEN1 (0.66) | HTR1ADRD2HTR2AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL19066024 | 0.75 | MEN1 (0.65) | HTR1ADRD2HTR2AMEN1KMT2A | |
| SCHEMBL7969931 | 0.75 | MEN1 (0.65) | HTR1ADRD2HTR2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3988453-A | Novel phenothiazines as neuroleptics | ROUSSEL-UCLAF (FR) | 1976-10-26 | — | — | US | disclosed |
| US-3950527-A | SEDATIVES | ROUSSEL-UCLAF (FR) | 1976-04-13 | — | — | US | disclosed |
| US-3947578-A | Omega-[4-(3\"-indolyl)-piperidino]-alkyl-arylketones as nevroleptics | ROUSSEL UCLAF (FR) | 1976-03-30 | — | — | US | disclosed |