Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 7/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178467 | 1.00 | SCARB1 (0.33) | SCARB1RETRORCPDE5AMALT1 | |
| SCHEMBL1420956 | 0.90 | SCARB1 (0.34) | SCARB1PDE5AHRH1HTR6GPR6 | |
| SCHEMBL2024064 | 0.89 | RORC (0.35) | SCARB1RETRORCPDE5AHRH1 | |
| SCHEMBL2024062 | 0.89 | RORC (0.35) | SCARB1RETRORCPDE5AHRH1 | |
| SCHEMBL1178293 | 0.87 | GPR6 (0.36) | SCARB1RETRORCHRH1HTR6 | |
| SCHEMBL1178295 | 0.87 | GPR6 (0.36) | SCARB1RETRORCHRH1HTR6 | |
| SCHEMBL16493840 | 0.86 | SCARB1 (0.35) | SCARB1RETRORCHRH1HTR6 | |
| SCHEMBL2026412 | 0.86 | RET (0.34) | SCARB1RETRORCHRH1HTR6 | |
| SCHEMBL2022401 | 0.86 | RET (0.34) | SCARB1RETRORCHRH1HTR6 | |
| SCHEMBL1177777 | 0.85 | HRH1 (0.35) | SCARB1RETRORCHRH1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486943-B2 | Tetrahydrocyclopenta[b]indole androgen receptor modulators | ELI LILLY AND COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486943-B2 | Tetrahydrocyclopenta[b]indole androgen receptor modulators | ELI LILLY AND COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| EP-2297100-B1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | ELI LILLY AND COMPANY (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | ELI LILLY AND COMPANY (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039855-A1 | Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators | AR, ADRA1B, ADRB1 | SCARB1 1215/4885RET 2574/4885RORC 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.