Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 9/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178469 | 0.90 | SCARB1 (0.33) | SCARB1PDE5AADAM17PTGDR2HRH1 | |
| SCHEMBL1178467 | 0.90 | SCARB1 (0.33) | SCARB1PDE5AADAM17PTGDR2HRH1 | |
| SCHEMBL13563337 | 0.80 | SCARB1 (0.49) | SCARB1PDE5AHRH1HTR6 | |
| SCHEMBL1420698 | 0.79 | GPR6 (0.37) | SCARB1PDE5AADAM17PTGDR2GPR6 | |
| SCHEMBL28633114 | 0.78 | HRH1 (0.47) | SCARB1PTGDR2HRH1HTR6 | |
| SCHEMBL28633113 | 0.78 | HRH1 (0.47) | SCARB1PTGDR2HRH1HTR6 | |
| SCHEMBL2024064 | 0.78 | RORC (0.35) | SCARB1PDE5APTGDR2HRH1HTR6 | |
| SCHEMBL2024062 | 0.78 | RORC (0.35) | SCARB1PDE5APTGDR2HRH1HTR6 | |
| SCHEMBL16493840 | 0.77 | SCARB1 (0.35) | SCARB1PTGDR2HRH1HTR6GPR6 | |
| SCHEMBL1178293 | 0.76 | GPR6 (0.36) | SCARB1HRH1HTR6GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297100-A1 | TETRAHYDROCYCLOPENTAÝB¨INDOLE ANDROGEN RECEPTOR MODULATORS | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009140448-A1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |