Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.97 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.97 |
| ▸ | TTR | P02766 | 3/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.97 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.97 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.97 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.97 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL2799 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL29354260 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL996716 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2216520 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL418230 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL4614418 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL40785 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22370200 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22129258 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1231246 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105916509-A | Compositions and methods for ophthalmic and/or other applications | 卡拉制药公司 | 2016-08-31 | — | — | CN | disclosed |
| EP-2995312-A1 | ANTI-INFLAMMATORY COMPOSITION BASED ON STRONTIUM COMPOUNDS | SantoSolve AS (NO) | 2016-03-16 | — | — | EP | disclosed |
| US-20150265649-A1 | STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN | SANTOSOLVE AS (NO) | 2015-09-24 | — | — | US | disclosed |
| EP-1605955-B1 | Anti-inflammatory composition based on strontium compounds | SANTOSOLVE AS (NO) | 2015-08-19 | — | — | EP | disclosed |
| US-9050312-B2 | Strontium compound for treatment of sub-dermal soft tissue pain | SANTOSOLVE AS (NO) | 2015-06-09 | — | — | US | disclosed |
| US-20110038953-A1 | STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN | SANTOSOLVE AS (NO) | 2011-02-17 | — | — | US | disclosed |
| CN-100415247-C | Strontium compounds for the treatment of subcutaneous soft tissue pain | SANTOSOLVE AS (NO) | 2008-09-03 | — | — | CN | disclosed |
| EP-1429792-B1 | STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN | SANTOSOLVE AS (NO) | 2008-03-19 | — | — | EP | disclosed |
| US-20070237836-A1 | Strontium compound for treatment of sub-dermal soft tissue pain | SANTOSOLVE AS | 2007-10-11 | — | — | US | disclosed |
| US-7241460-B2 | Strontium compound for treatment of sub-dermal soft tissue pain | SANTOSOLVE AS (NO) | 2007-07-10 | — | — | US | disclosed |
| CN-1981780-A | Strontium compound for treatment of sub-dermal soft tissue pain | SANTOSOLVE AS (NO) | 2007-06-20 | — | — | CN | disclosed |
| US-20070053994-A1 | Anti-inflammatory treatment | SANA PHARMA MEDICAL AS (NO) | 2007-03-08 | — | — | US | disclosed |
| EP-1741436-A1 | Strontium compound for treatment of sub-dermal soft tissue pain | Santosolve AS (NO) | 2007-01-10 | — | — | EP | disclosed |
| EP-1605955-A2 | ANTI-INFLAMMATORY COMPOSITION BASED ON STRONTIUM COMPOUNDS | Santosolve AS (NO) | 2005-12-21 | — | — | EP | disclosed |
| US-20050013877-A1 | Strontium compound for treatment of sub-dermal soft tissue pain | SANA PHARMA MEDICAL AS (NO) | 2005-01-20 | — | — | US | disclosed |
| WO-2004084920-A2 | ANTI-INFLAMMATORY TREATMENT BASED ON STRONTIUM COMPOUNDS | SANTOSOLVE AS (NO) | 2004-10-07 | — | — | WO | disclosed |
| EP-1429792-A1 | STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN | Santosolve AS (NO) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003028742-A1 | STRONTIUM COMPOUND FOR TREATMENT OF SUB-DERMAL SOFT TISSUE PAIN | SANTOSOLVE AS (NO) | 2003-04-10 | — | — | WO | disclosed |