Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.97 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.97 |
| ▸ | TTR | P02766 | 3/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.97 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.97 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.97 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.97 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL2799 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL29354260 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL996716 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2216520 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22129258 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1178502 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL40785 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22370200 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL418230 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1231246 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572152-B1 | LIPOSOMAL ANALGESIC FORMULATION COMPRISING DICLOFENAC AND ITS USE FOR TREATMENT OF HORSES | IDEXX LAB INC (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1572152-A4 | LIPOSOMAL ANALGESIC FORMULATION AND USE | IDEXX LAB INC (US) | 2006-04-05 | — | — | EP | disclosed |
| EP-1572152-A2 | LIPOSOMAL ANALGESIC FORMULATION AND USE | IDEXX LABORATORIES, INC. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004057950-A2 | LIPOSOMAL ANALGESIC FORMULATION AND USE | IDEXX LABORATORIES, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| US-20040131667-A1 | Liposomal analgesic formulation and use | IDEXX LABORATORIES, INC. | 2004-07-08 | — | — | US | disclosed |