Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.97 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.97 |
| ▸ | TTR | P02766 | 3/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.97 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.97 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.97 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.97 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL29354260 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL996716 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2799 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL418230 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22370200 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL3184302 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1231246 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22129258 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL24010 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL4614418 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101433544-B | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL SCIENCE & TECHNOLOGY INC | 2012-07-18 | — | — | CN | claimed |
| CN-101433544-A | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL (CN) | 2009-05-20 | — | — | CN | claimed |
| US-20070213406-A1 | Anti-Inflammatory Analgesic External Aqueus Liquid Preparation | DOJIN IYAKU-KAKO CO., LTD (JP) | 2007-09-13 | — | — | US | claimed |
| EP-0600395-B1 | Antinflammatory and analgesic diclofenac gel preparation | SS PHARMACEUTICAL CO (JP) | 2000-03-15 | — | — | EP | claimed |
| US-5422102-A | Diclofenac or salt with nonionic polymer of hydroxypropyl and/or hydroxyethyl cellulose; percutaneous adsorption | SS PHARMACEUTICAL CO., LTD. (JP) | 1995-06-06 | — | — | US | claimed |
| EP-0600395-A1 | Antinflammatory and analgesic diclofenac gel preparation | SS PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | claimed |
| JP-10182450-A | — | — | None | — | — | JP | disclosed |
| WO-2024062349-A1 | HYDROALCOHOLIC TOPICAL DICLOFENAC FORMULATIONS | HALEON CH SARL (CH) | 2024-03-28 | — | — | WO | disclosed |
| WO-2024062348-A1 | HYDROALCOHOLIC SINGLE PHASE GEL COMPOSITIONS FOR TOPICAL DELIVERY OF DICLOFENAC | HALEON CH SARL (CH) | 2024-03-28 | — | — | WO | disclosed |
| EP-4342449-A1 | HYDROALCOHOLIC SINGLE PHASE GEL COMPOSITIONS FOR TOPICAL DELIVERY OF DICLOFENAC | Haleon CH SARL (CH) | 2024-03-27 | — | — | EP | disclosed |
| EP-4342450-A1 | HYDROALCOHOLIC TOPICAL DICLOFENAC FORMULATIONS | Haleon CH SARL (CH) | 2024-03-27 | — | — | EP | disclosed |
| WO-2020133015-A1 | CYPYRAFLUONE MONOISOPROPYLAMINE SALT D CRYSTAL FORM, PREPARATION METHOD THEREFOR AND USE THEREOF | 青岛清原化合物有限公司 | 2020-07-02 | — | — | WO | disclosed |
| WO-2020133013-A1 | CRYSTALLINE FORM B OF CYPYRAFLUONE ISOPROPYLAMINE SALT, AND PREPARATION METHOD AND USE THEREFOR | 青岛清原化合物有限公司 | 2020-07-02 | — | — | WO | disclosed |
| US-20070213406-A1 | Anti-Inflammatory Analgesic External Aqueus Liquid Preparation | DOJIN IYAKU-KAKO CO., LTD (JP) | 2007-09-13 | — | — | US | disclosed |
| CN-1200696-C | Patch containing anti-inflammatory agent | HISAMITSU PHARMACEUTICAL CO (JP) | 2005-05-11 | — | — | CN | disclosed |
| US-20030149383-A1 | Patch containing anti-inflammatory agent | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2003-08-07 | — | — | US | disclosed |
| CN-1424908-A | Patch containing anti-inflammatory agent | HISAMITSU PHARMACEUTICAL CO (JP) | 2003-06-18 | — | — | CN | disclosed |
| EP-1277466-A1 | PATCH CONTAINING ANTI-INFLAMMATORY AGENT | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2003-01-22 | — | — | EP | disclosed |
| JP-H10182450-A | COMPOSITION FOR EXTERNAL USE | SS PHARMACEUT CO LTD | 1998-07-07 | — | — | JP | disclosed |
| US-5350769-A | Sodium or ammonium diclofenac, a nonionic polymer, an ester of a diacid and an lower alcohol | SS PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |