Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349824 | 0.87 | SMN1; SMN2 (0.48) | RAB9ALMNATSHRCYP3A4CYP2D6 | |
| SCHEMBL4209923 | 0.86 | LMNA (0.46) | RAB9ALMNATSHRCYP3A4CYP2D6 | |
| SCHEMBL1178846 | 0.86 | ATM (0.49) | TSHRMAPTATMSMN1; SMN2P2RX7 | |
| Hydrochloric Acid SCHEMBL4203364 | 0.84 | ATM (0.48) | TSHRCYP3A4CYP2D6MAPTATM | |
| Hydrochloric Acid SCHEMBL4206022 | 0.84 | LMNA (0.47) | RAB9ALMNATSHRCYP3A4CYP2D6 | |
| SCHEMBL1178410 | 0.83 | ATM (0.41) | RAB9ALMNATSHRMAPTATM | |
| SCHEMBL1178550 | 0.83 | ATM (0.47) | RAB9ATSHRMAPTATMSMN1; SMN2 | |
| SCHEMBL1178772 | 0.81 | TSHR (0.46) | RAB9ALMNATSHRCYP3A4CYP2D6 | |
| SCHEMBL1178751 | 0.80 | KMT2A (0.46) | P2RX7 | |
| SCHEMBL1178882 | 0.80 | GAA (0.56) | RAB9ALMNATSHRMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459542-B1 | Substituted N-benzyl-4,5-dihydrooxazol-2-amines useful as selective alpha 2B/2C receptor agonists | ALLERGAN INC (US) | 2014-10-29 | — | — | EP | disclosed |
| EP-2459542-B1 | Substituted N-benzyl-4,5-dihydrooxazol-2-amines useful as selective alpha 2B/2C receptor agonists | ALLERGAN INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-8329918-B2 | Selective alpha 2B/2C agonists | ALLERGAN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329918-B2 | Selective alpha 2B/2C agonists | ALLERGAN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329918-B2 | Selective alpha 2B/2C agonists | ALLERGAN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-2459542-A1 | SELECTIVE ALPHA 2B/2C AGONISTS | Allergan, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ALLERGAN, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ALLERGAN, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ALLERGAN, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| WO-2011014332-A1 | SELECTIVE ALPHA 2B/2C AGONISTS | ALLERGAN, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011014332-A1 | SELECTIVE ALPHA 2B/2C AGONISTS | ALLERGAN, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ADRA2C, ADRA2B, ADRB2 | RAB9A 1710/4885LMNA 1628/4885TSHR 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.