Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flufenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.55 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flufenamic Acid SCHEMBL1478282 | 0.88 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL29438087 | 0.88 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL9845498 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL11524550 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL11788728 | 0.85 | RXFP1 (0.71) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL11794349 | 0.78 | RXFP1 (0.60) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL11793234 | 0.77 | RXFP1 (0.57) | RXFP1YAP1TEAD4TEAD2MPO | |
| Flufenamic Acid SCHEMBL11791445 | 0.77 | RXFP1 (0.57) | RXFP1YAP1TEAD4TEAD2MPO | |
| SCHEMBL9270625 | 0.76 | RXFP1 (0.73) | RXFP1YAP1TEAD4TEAD2ALDH1A1 | |
| Flufenamic Acid SCHEMBL17497 | 0.75 | RXFP1 (0.75) | RXFP1YAP1TEAD4TEAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3988333-A | Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |