Flufenamic Acid

Flufenamic Acid

SCHEMBL17497

O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.75
MPO P05164 6/20 0.73
GRIK1 P39086 1/20 0.73
TEAD4 Q15561 2/20 0.71
YAP1 P46937 1/20 0.71
TEAD2 Q15562 1/20 0.71
TAS2R14 Q9NYV8 5/20 0.69
AURKA O14965 1/20 0.69
MAPK8 P45983 1/20 0.69
AKR1C3 P42330 2/20 0.68
AKR1C2 P52895 2/20 0.68
ADRA2B P18089 1/20 0.64
ADRA2C P18825 1/20 0.64
MEN1 O00255 1/20 0.64
GMNN O75496 1/20 0.64
ALDH1A1 P00352 1/20 0.64
LMNA P02545 1/20 0.64
TTR P02766 1/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flufenamic Acid SCHEMBL29356958 1.00 RXFP1 (0.75) RXFP1MPOGRIK1TEAD4YAP1
Flufenamic Acid SCHEMBL11524554 0.99 RXFP1 (0.73) RXFP1MPOGRIK1TEAD4YAP1
Flufenamic Acid SCHEMBL9845499 0.99 RXFP1 (0.73) RXFP1MPOGRIK1TEAD4YAP1
SCHEMBL8416271 0.92 RXFP1 (0.81) RXFP1MPOGRIK1
Flufenamic Acid SCHEMBL10531046 0.89 MPO (0.67) RXFP1MPOGRIK1TEAD4YAP1
SCHEMBL19002050 0.89 TAS2R14 (0.62) RXFP1MPOGRIK1TEAD4YAP1
SCHEMBL11330727 0.88 TAS2R14 (0.82) RXFP1MPOGRIK1TAS2R14AKR1C3
SCHEMBL19657901 0.87 RXFP1 (0.70) RXFP1MPOGRIK1TEAD4YAP1
SCHEMBL9522037 0.87 YAP1 (0.74) RXFP1MPOGRIK1TEAD4YAP1
SCHEMBL12851592 0.87 RXFP1 (0.78) RXFP1MPOTEAD4YAP1TEAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 36258 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
CN-122056860-A Application of flufenamic acid in preparation of polymyxin E antibacterial synergist 新疆农垦科学院 2026-05-19 CN claimed
US-20260130928-A1 COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN ASCENTAWITS PHARMACEUTICALS LTD (CN) 2026-05-14 US claimed
EP-4741492-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2026-05-13 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260115192-A1 PHARMACEUTICAL COMPOSITIONS SHENZHEN PHARMACIN CO LTD (CN) 2026-04-30 US claimed
US-12605432-B2 Combinations for antigen based therapy DIAMYD MEDICAL AB (SE) 2026-04-21 US claimed
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US claimed
US-12545750-B2 Method for the diimide hydrogenation of emulsified unsaturated polymers PARKER DANE K (US) 2026-02-10 US claimed
EP-4683527-A1 VAPORIZABLE ALKALOID COMPOSITIONS AND METHODS OF USE THEREOF Ready Mix Naturals, LLC (US) 2026-01-28 EP claimed
EP-0040899-A2 Method of delivering drug with aid of effervescent activity generated in environment of use ALZA CORPORATION (US) 1981-12-02 EP claimed
EP-0039051-A2 Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them MERCK & CO. INC. (US) 1981-11-04 EP claimed
US-4272529-A ANTIINFLAMMATORY SIMES S.P.A. (IT) 1981-06-09 US claimed
US-4260613-A ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC CRINOS INDUSTRIA FARMACOBIOLOGICA S.P.A. (IT) 1981-04-07 US claimed
US-4247554-A ADMINISTERING A QUINAZOLINONE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-01-27 US claimed
EP-0016460-A1 Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition NEOPHARMED S.p.A. (IT) 1980-10-01 EP claimed
US-4198431-A ANTIINFLAMMATORY HOKURIKU PHARMACEUTICAL CO., LTD. (JP) 1980-04-15 US claimed
US-4123534-A VIGILANCE INCREASING AGENTS Wulfing, Johann W. (DE) 1978-10-31 US claimed
US-4091095-A DIALKYLPHOSPHINYL-ALKYL ESTER OF A 2-(ARYL-AMINO) BENZOIC ACID, ANALGESICS HOECHST AKTIENGESELLSCHAFT (DT) 1978-05-23 US claimed
US-4024279-A Treatment of dysmenorrhea and migraine symptoms YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1977-05-17 US claimed