Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11806735 | 0.89 | CA2 (0.48) | CA1CA2CA9LMNAMEN1 | |
| SCHEMBL11847444 | 0.89 | ALDH1A1 (0.47) | CA2LMNAHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL11799395 | 0.83 | LMNA (0.59) | LMNAMEN1KMT2APOLBHSD17B10 | |
| SCHEMBL11778072 | 0.81 | CA1 (0.46) | CA1CA2CA9LMNAMEN1 | |
| SCHEMBL11844827 | 0.78 | LMNA (0.45) | CA2LMNAKMT2APOLBHSD17B10 | |
| SCHEMBL11801560 | 0.77 | LMNA (0.48) | CA1CA2CA9LMNAMEN1 | |
| SCHEMBL11849419 | 0.76 | ALDH1A1 (0.49) | CA2LMNAHSD17B10ALDH1A1HPGD | |
| SCHEMBL28945970 | 0.74 | ALDH1A1 (0.50) | CA2LMNAHSD17B10ALDH1A1HPGD | |
| SCHEMBL30241206 | 0.74 | ALDH1A1 (0.50) | CA2LMNAHSD17B10ALDH1A1HPGD | |
| SCHEMBL11800292 | 0.73 | LMNA (0.60) | CA1CA2CA9LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992440-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |
| US-3982018-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-09-21 | — | — | US | disclosed |
| US-3939267-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |