Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895093 | 0.82 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1LMNA | |
| Nitric Acid SCHEMBL11797604 | 0.80 | CYP3A4 (0.41) | ALDH1A1SMN1; SMN2CNR2MEN1POLB | |
| SCHEMBL29114655 | 0.76 | SIGMAR1 (0.54) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Nitric Acid SCHEMBL11803546 | 0.75 | AOC3 (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Nitric Acid SCHEMBL11809174 | 0.73 | HTT (0.33) | ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1937338 | 0.73 | ALDH1A1 (0.47) | SIGMAR1ALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL1937395 | 0.73 | ALDH1A1 (0.47) | SIGMAR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27173948 | 0.72 | IDO1 (0.43) | SIGMAR1ALDH1A1TDP1 | |
| Nitric Acid SCHEMBL11800638 | 0.71 | CYP2C19 (0.43) | ALDH1A1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL10493836 | 0.71 | CNR2 (0.43) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3960949-A | DIABETES | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-06-01 | — | — | US | disclosed |