Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL11797604 | 0.80 | CYP3A4 (0.41) | ALDH1A1GAAMEN1KMT2ANPSR1 | |
| SCHEMBL29002161 | 0.79 | PSEN1 (0.36) | ALDH1A1HPGDMEN1KMT2ANPSR1 | |
| Nitric Acid SCHEMBL11800644 | 0.73 | NR1D1 (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11236179 | 0.70 | LMNA (0.41) | HTTALDH1A1 | |
| SCHEMBL18762978 | 0.69 | CYP3A4 (0.44) | ALDH1A1GAAMEN1KMT2ANPSR1 | |
| SCHEMBL14868762 | 0.67 | HTR3E (0.41) | ALDH1A1HPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL29044110 | 0.66 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2A | |
| Nitric Acid SCHEMBL11797597 | 0.66 | PTGIR (0.46) | HTTALDH1A1GAAHPGDMEN1 | |
| Nitric Acid SCHEMBL11800638 | 0.64 | CYP2C19 (0.43) | ALDH1A1HPGDMEN1KMT2A | |
| Nitric Acid SCHEMBL2544082 | 0.64 | NPC1 (0.53) | HTTALDH1A1GAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3960949-A | DIABETES | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-06-01 | — | — | US | disclosed |