Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762978 | 0.90 | CYP3A4 (0.44) | CYP3A4ALDH1A1CNR2MEN1KMT2A | |
| Nitric Acid SCHEMBL11809174 | 0.80 | HTT (0.33) | ALDH1A1MEN1KMT2ANPSR1GAA | |
| Nitric Acid SCHEMBL11800644 | 0.80 | NR1D1 (0.37) | ALDH1A1CNR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18763006 | 0.76 | MEN1 (0.40) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL18763007 | 0.76 | MAPT (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL18762979 | 0.75 | MEN1 (0.57) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11191152 | 0.75 | NPC1 (0.41) | CYP3A4ALDH1A1CNR2SMN1; SMN2KDM4E | |
| SCHEMBL3025013 | 0.75 | SIGMAR1 (0.36) | CYP3A4ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL18762983 | 0.74 | HTR3E (0.51) | CYP3A4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9615764 | 0.73 | LMNA (0.37) | CYP3A4ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3960949-A | DIABETES | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-06-01 | — | — | US | disclosed |