Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.74 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | GLUL | P15104 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL29050532 | 0.96 | GSR (0.74) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL30839526 | 0.93 | GSR (0.74) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL1666689 | 0.93 | GSR (0.74) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL27653586 | 0.93 | GSR (0.74) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL28434271 | 0.92 | GSR (0.80) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL27632944 | 0.92 | GSR (0.80) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL1666693 | 0.92 | GSR (0.80) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL1666691 | 0.92 | GSR (0.80) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL28010048 | 0.91 | GSR (0.71) | GSRARG2ARG1OTCRNPEP | |
| Lysine SCHEMBL103555 | 0.90 | GSR (0.83) | GSRARG2ARG1OTCRNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3932608-A | 1A, 2A-AMINO ACID PHOSPHATES, CARIOSTATIC AGENTS | GENERAL MILLS, INC. (US) | 1976-01-13 | — | — | US | claimed |
| US-3943241-A | Cariostatic composition | GENERAL MILLS, INC. (US) | 1976-03-09 | — | — | US | disclosed |
| US-3932608-A | 1A, 2A-AMINO ACID PHOSPHATES, CARIOSTATIC AGENTS | GENERAL MILLS, INC. (US) | 1976-01-13 | — | — | US | disclosed |