Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057724 | 0.79 | MTNR1A (0.38) | MTNR1AMTNR1BTSHRLTA4HKCNA3 | |
| SCHEMBL8108204 | 0.79 | MTNR1A (0.42) | MTNR1AMTNR1BTSHRLTA4HKCNA3 | |
| SCHEMBL6482154 | 0.79 | TAAR1 (0.41) | MTNR1AMTNR1BTSHRLTA4HKCNA3 | |
| SCHEMBL11208071 | 0.79 | KCNA3 (0.41) | MTNR1AMTNR1BTSHRKCNA3SLC6A4 | |
| SCHEMBL15349936 | 0.77 | LMNA (0.50) | MTNR1AMTNR1BKCNA3PPARGPPARA | |
| SCHEMBL10372698 | 0.76 | SLC6A4 (0.41) | MTNR1AMTNR1BLTA4HSLC6A4PPARG | |
| SCHEMBL28025173 | 0.76 | LMNA (0.44) | LMNA | |
| SCHEMBL9674388 | 0.74 | MTNR1A (0.50) | MTNR1AMTNR1BLTA4HSLC6A4SLC6A2 | |
| SCHEMBL10358911 | 0.74 | LMNA (0.42) | MTNR1AMTNR1BTSHRLTA4HKCNA3 | |
| SCHEMBL8089903 | 0.74 | CYP2C19 (0.39) | MTNR1AMTNR1BTSHRLTA4HKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3981888-A | Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid | MERCK & CO., INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3950408-A | Process for preparing [1-oxo-2-cyclopentyl (or 2-isopropyl)-2-methyl-6,7-dichloro-5-indanyloxy] acetic acid | MERCK & CO., INC. (US) | 1976-04-13 | — | — | US | disclosed |