SCHEMBL11813645

SCHEMBL11813645

CC(N)c1ccc([N+](=O)[O-])cc1.NCc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.70
IDO1 P14902 3/20 0.46
KCNJ1 P48048 1/20 0.45
KCNH2 Q12809 1/20 0.45
ALDH1A1 P00352 6/20 0.44
MAPT P10636 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
KDM4E B2RXH2 2/20 0.44
USP2 O75604 1/20 0.44
LMNA P02545 1/20 0.44
TSHR P16473 2/20 0.43
ACHE P22303 2/20 0.43
BCHE P06276 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPK1 P28482 1/20 0.42
PHLPP2 Q6ZVD8 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
GAA P10253 1/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL352795 0.88 ALDH1A1 (0.52) LOXL2ALDH1A1MAPTL3MBTL1KDM4E
SCHEMBL353942 0.88 ALDH1A1 (0.52) LOXL2ALDH1A1MAPTL3MBTL1KDM4E
SCHEMBL811522 0.88 ALDH1A1 (0.52) LOXL2ALDH1A1MAPTL3MBTL1KDM4E
Hydrochloric Acid SCHEMBL913942 0.86 ALDH1A1 (0.50) LOXL2IDO1ALDH1A1MAPTL3MBTL1
Ammonia Solution, Strong SCHEMBL4826153 0.86 ALDH1A1 (0.50) LOXL2ALDH1A1MAPTL3MBTL1KDM4E
Hydrochloric Acid SCHEMBL248092 0.86 ALDH1A1 (0.50) LOXL2IDO1ALDH1A1MAPTL3MBTL1
Hydrochloric Acid SCHEMBL913941 0.86 ALDH1A1 (0.50) LOXL2IDO1ALDH1A1MAPTL3MBTL1
SCHEMBL354332 0.84 LOXL2 (1.00) LOXL2IDO1KCNJ1KCNH2ALDH1A1
SCHEMBL30913865 0.82 CA12 (0.53) LOXL2ALDH1A1MAPTL3MBTL1KDM4E
Hydrochloric Acid SCHEMBL726 0.82 LOXL2 (0.95) LOXL2IDO1KCNJ1KCNH2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3965129-A THREO-EPOXYACONITIC ACID BIS-R(+)-ALPHA-METHYL-P-NITROBENZYLAMINE SALT HOFFMANN-LA ROCHE INC. (US) 1976-06-22 US disclosed